Formulation and Evaluation of Orodispersible Tablets Containing Co-Crystals of Modafinil

Background: Modafinil is a CNS stimulant used to treat Narcolepsy, sleepiness and other disorders related sleep. It BCS class II drug having poor aqueous solubility.
 Objective: This study was aimed formulate evaluate orodispersible tablets of containing co-crystals for the improvisation critical attributes product such as dissolution rates, solubility oral bioavailability.
 Methods: Co-crystals were prepared by dry grinding method using Sodium acetate, Nicotinic acid, Benzoic Urea Succinic acetate co-formers. Tablets compressed direct compression SSG, Crospovidone, Croscarmellose sodium super disintegrants in different concentration.
 Results: Pre-formulation studies performed evaluation revealed that formulated with showed best results. The manufactured evaluated parameters including weight variation, hardness, thickness, friability, content, In-vitro disintegration studies. Formulation F2 shows significant change rate also helped increase poorly water soluble drugs both them i.e. percentage release are key factors exhibit efficiency drug. co-crystal 1:1 ratio highest content (97.97%), while acid 1:2 least (56.48%).
 Conclusion: According result obtained, an tablet modafinil enhances rate, hence increases therapeutic efficacy could be considered convenient delivery systems enhance Keywords: Co-crystal, Oro-dispersible, Sleepiness